Non-random karyotypic changes in Djungarian hamster tumors induced by 3-methylcholanthrene.

The karyotypes of 30 tumors (sarcomas and adenocarcinomas) induced with methylcholanthrene in Djungarian hamsters (Phodopus sungorus campbelli) have been investigated. In 23 tumors structural changes of the short arm of X-chromosome (Xp+ or Xp = type) were revealed. Non-random rearrangements of 3p, 7q and 8q were also observed.

Nonrandom chromosomal changes in retinoblastomas.

The analysis of the karyotype in 76 retinoblastomas (24 our cases and 52 described in the literature) has revealed nonrandom changes of Iq, 6p, 13, 16 and the sex chromosomes. Complete or partial trisomy Iq was observed in 44 out of 76 tumours. Tetra-or trisomy 6p was found in 35 and 6 cases respectively.

An ovarian cancer family: clinical and cytogenetic data.

A family with five ovarian neoplasms in three subsequent generations was studied. Four women had ovarian cancer at age 38, 40, 47, and 53, and one had cystoma ovari at 24. There were other neoplasms and preneoplastic lesions in this family.

Similar chromosomal abnormalities in several retinoblastomas.

The study of banded chromosomes of nine sporadic unilateral retinoblastomas revealed near diploid karyotypes with multiple numerical and (or) structural abnormalities in all tumors. An identical marker i(6p) was noted in cells of the modal class of six retinoblastomas. Extra copies of the short arm of chromosome 6 were observed in seven tumors: +i(6p) in 6 and +6q-in one.