Publications by authors named "H E MAYES"
Type 2 diabetes (T2D) is a metabolic disease associated with cardiovascular dysfunction. The myocardium preferentially uses ketones over free fatty acids as a more energy efficient substrate. The primary aim was to assess the effects of ketone monoester (K) ingestion on cardiac output index ().
View Article and Find Full Text PDFHigh altitude residents have a lower incidence of type 2 diabetes mellitus (T2DM). Therefore, we examined the effect of repeated overnight normobaric hypoxic exposure on glycaemic control, appetite, gut microbiota and inflammation in adults with T2DM. Thirteen adults with T2DM [glycated haemoglobin (HbA1): 61.
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- Polyethylene terephthalate (PET) can be broken down by the PETase enzyme from Ideonella sakaiensis, with a proposed reaction pathway involving a two-step mechanism using a catalytic triad of serine, histidine, and aspartate.
- Researchers applied transition path sampling and likelihood maximization to identify key reaction coordinates in the PETase catalytic process, predicting that deacylation is the slowest step and involving processes like nucleophilic attack and ester bond cleavage.
- The study highlights the role of Trp185's flexibility in enhancing the reaction speed and offers insights for engineering enzymes that can more effectively convert plastics through bioconversion.
Introduction: Both sleep deprivation and hypoxia have been shown to impair executive function. Conversely, moderate intensity exercise is known to improve executive function. In a multi-experiment study, we tested the hypotheses that moderate intensity exercise would ameliorate any decline in executive function after i) three consecutive nights of partial sleep deprivation (PSD) (Experiment 1) and ii) the isolated and combined effects of a single night of total sleep deprivation (TSD) and acute hypoxia (Experiment 2).
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- - The study explored the effects of repeated hot water immersion (HWI) on insulin sensitivity and inflammation in individuals with type 2 diabetes mellitus (T2DM), finding that it improved fasting insulin sensitivity and reduced plasma insulin levels.
- - Fourteen T2DM participants underwent HWI, with significant improvements in metabolic efficiency indicated by a 6.63% reduction in resting metabolic rate (RMR), although other measures like blood glucose and inflammatory markers showed no notable changes.
- - This research is the first to focus on HWI for improving metabolic health in T2DM, suggesting that repeated hot water treatments can potentially enhance insulin function and overall metabolic outcomes.