Divergent changes of flow through individual blood vessels upon localized heating.

The changes of microregional perfusion in a hamster cheek pouch membrane were investigated. The vessel network of the membrane was visualized by preparing a transparent chamber, which was heated with circulating water at 42 degree C. Blood perfusion was monitored by using a laser Doppler flowmeter (LDF), which was used either in a conventional way by positioning the probe stationary or in a novel way by constantly moving the probe over the surface of the chamber (scanning).

Combined antitumor effect of suramin plus irradiation in human prostate cancer cells: the role of apoptosis.

Suramin has recently surfaced as a potential antineoplastic agent on the basis of its ability to exert a cytostatic effect on human prostate carcinoma cells. Radiotherapy for the treatment of prostate cancer has long been known as an alternative medical therapeutic approach, but the molecular mechanism involved in radiation-induced toxicity in prostatic tumors is poorly defined. In these studies, the antitumor effect of suramin and irradiation, either as individual treatments or in combination, was investigated in human prostate cancer cells.

Long-term persistence of sterile immunity in a volunteer immunized with X-irradiated Plasmodium falciparum sporozoites.

Three volunteers were immunized by repeated exposure to the bites of Plasmodium falciparum-infected, X-irradiated mosquitoes to characterize immunologic responses and duration of protective immunity. A primary series of immunizations had been shown previously to induce sterile immunity in these volunteers against sporozoite-induced P. falciparum malaria.