[Local use of cytostatic drugs following removal of glioblastomas].

Local application of Methotrexate after removal of glioblastomas enables a high chemotherapeutic concentration to be achieved in the wall of the surgical cavity without appreciable side effects on sensitive structures of the body. This procedure, followed by intravenous chemotherapy may prevent local recurrence, on the assumption that glioblastoma recurrences originate in the operation site. Five groups (269 patients) subjected to different strategies of postoperative therapy were compared in terms of average survival time.

[Carpal tunnel syndrome as an unrecognized disease in the aged].

Although the symptoms are very characteristical (in our patients 91,5% pain, 69,2% disturbed sensibility and 29,2% weakness) and the neurological diagnosis is typical (82,9% disturbed sensibility, 30,6% weakness, 57,1% atrophy of the thenar muscle) faults in diagnosis are possible. Particularly in old age it is mistaken for vertebral or vascular diseases. If conservative treatment is ineffective or the compression of the nerve is enlarging fast, surgical treatment will be indicated.

[Importance of computerized tomography for surgical treatment of intracranial hematomas (author's transl)].

The improved treatment by using computerized tomography (CT) located between operating theater and intensive care unit is reported in comparison of 3,382 patients with severe head injuries. By preoperative use of CT the frequency of diagnosed hematomas was about the same (29.5% before CT; 27.

[Pseudodementia in frontal tumours (author's transl)].

Our examinations have revealed personality changes in eighteen out of fifty patients with frontal tumour. The changes may be classified to a certain extent in the same symptomatological category as pseudodementia. In view of the site, size and histological structure of the tumours, the existence and severity of the disorders seem to be independent of tumour vascularization.