Publications by authors named "H E Bazan"
Background: Stroke requires timely intervention, with carotid endarterectomy (CEA) and carotid artery stenting (CAS) increasingly used in select acute carotid-related stroke patients. We aimed to build a model to predict neurologic functional independence (modified Rankin scale, mRS ≤ 2) in this high-risk group.
Study Design: We analyzed data from 302 stroke patients undergoing urgent CEA or CAS between 2015 and 2023 at a tertiary Comprehensive Stroke Center.
Article Synopsis
- Carotid artery disease significantly contributes to ischemic strokes, and urgent carotid interventions such as uCEA and uCAS are critical for at-risk patients, particularly the elderly.
- A study examined 307 stroke patients to develop a frailty-based risk score that predicts outcomes like stroke, death, and myocardial infarction following these procedures, with comorbidities like hypertension being prevalent.
- Results showed that higher frailty scores correlate with increased risks post-procedure, emphasizing the need for careful patient selection based on health status and frailty.
Safe and effective pain management is a critical healthcare and societal need. The potential for acute liver injury from paracetamol (ApAP) overdose; nephrotoxicity and gastrointestinal damage from chronic non-steroidal anti-inflammatory drug (NSAID) use; and opioids' addiction are unresolved challenges. We developed SRP-001, a non-opioid and non-hepatotoxic small molecule that, unlike ApAP, does not produce the hepatotoxic metabolite N-acetyl-p-benzoquinone-imine (NAPQI) and preserves hepatic tight junction integrity at high doses.
View Article and Find Full Text PDFA new R,R-RvD6 isomer with protective actions following corneal nerve injury.
Prostaglandins Other Lipid Mediat
February 2024
Article Synopsis
- The cornea, the clear front part of the eye, has the highest concentration of nerve endings in the body, which are essential for maintaining sensitivity and tear production; damage to these nerves can lead to dry eye and ocular pain.
- A combined treatment using pigment epithelium-derived factor (PEDF) and docosahexaenoic acid (DHA) promotes nerve regeneration in the cornea after injury, especially through a newly synthesized resolvin D6 isomer called R,R-RvD6.
- Administering R,R-RvD6 topically in studies showed increased effectiveness in regenerating corneal nerves and reducing pain associated with dry eye compared to the original PEDF+DHA treatment.
Background: Carotid interventions are increasingly performed in select patients following acute stroke. We aimed to determine the effects of presenting stroke severity (National Institutes of Health Stroke Scale [NIHSS]) and use of systemic thrombolysis (tissue plasminogen activator [tPA]) on discharge neurological outcomes (modified Rankin scale [mRS]) after urgent carotid endarterectomy (uCEA) and urgent carotid artery stenting (uCAS).
Methods: Patients undergoing uCEA/uCAS at a tertiary Comprehensive Stroke Center (January 2015 to May 2022) were divided into two cohorts: (1) no thrombolysis (uCEA/uCAS only) and (2) use of thrombolysis before the carotid intervention (tPA + uCEA/uCAS).