[Assessment of the influence of puberty on changes in post exercise glycaemia after variable intensity physical effort in children and adolescents with diabetes mellitus type 1 (DM1)].

Introduction: During the pubertal period the metabolic control is getting worse in the most of patients with type 1 diabetes mellitus (DM1). The insufficient metabolic control may impact the post-exercise glycaemia and cause the acute complications of the diabetes.

Aim Of The Study: was to assess the influence of puberty on changes in post exercise glycaemia after variable intensity physical effort in children and adolescents with diabetes mellitus type 1 (DM1).

Insulin-like growth factor-1 and its binding proteins, IGFBP-1 and IGFBP-3, in adolescents with type-1 diabetes mellitus and microalbuminuria.

Background/aims: Numerous clinical and experimental studies suggest that growth factors may contribute to the development of diabetic microvascular complications. The aim of the study was to test the hypothesis that in adolescents with type-1 diabetes mellitus and microalbuminuria (MA) there are specific disorders of serum insulin-like growth factor-1 (IGF-1) and concentrations of its binding proteins, IGFBP-1 and IGFBP-3, that could be of importance in the pathogenesis of microvascular diabetic complications.

Methods: 25 adolescents with MA, 24 adolescents with diabetes without complications, and 17 controls were examined.

[Incidence of Graves disease in children in some regions of south-eastern Poland].

The aim of the studies was the assessment of Graves disease (G-D) incidence in children aged 0-15 years who inhabited the Krakowskie (K), Nowosadeckie (N) and Rzeszowskie (Rz) provinces in the years 1989-1996. The incidence of G-D was evaluated depending on the age, sex and place of residence (urban vs. rural area).

Interleukin-6 (IL-6) and IGF-IGFBP system in children and adolescents with type 1 diabetes mellitus.

Background: Some studies suggest that IL-6 is connected with glucose metabolism and insulin action, so like IGF-IGFBPs system it could play the role in diabetes etiopathogenesis.

Aim: The aim of the study was therefore to test the hypothesis that in children and adolescents IL-6 is of importance for the etiopathogenesis of diabetes mellitus type 1 and that IL-6 is connected with carbohydrate metabolism and IGF-IGFBPs action.

Methods: There were 49 patients with type 1 diabetes: 10 persons at onset diabetes and 39 with disease lasted at least 1 year and 33 age-matched healthy children included into the study.

[Thyroid peroxidase antibodies and thyroid diseases in children and adolescents with type 1 diabetes mellitus from Southeast Poland].

The authors evaluated the prevalence of TPO Ab and thyroid disorders in 219 children and adolescents (119/54% girls) with type 1 diabetes from southeast Poland aged 3.2-22.3 years (mean age-13.