Lithotripsy plus ursodiol is superior to ursodiol alone for cholesterol gallstones.

The safety and efficacy of gallbladder extracorporeal shock-wave lithotripsy combined with 600 mg/day ursodiol were examined in 85 patients with radiolucent gallstones, 15 with lightly calcified gallstones, and 12 with radiolucent stones pretreated for greater than or equal to 2 months with 600 mg/day ursodiol. Results were compared with those of a well-matched lithotripsy-eligible group of 32 subjects treated with ursodiol alone (no lithotripsy). Pretreatment with ursodiol significantly improved while gallstone calcification interfered with fragmentation.

Sonographic gallstone patterns are of value in predicting the outcome of biliary lithotripsy.

The purpose of our study was to determine whether the qualitative features of gallstones, as expressed by their sonographic image, are related to the degree of fragmentation by shock-wave lithotripsy and the rate of stone clearance. The sonographic stone images of 73 patients with 1-3 uncalcified gallstones, followed for at least 1 yr after extracorporeal shock-wave lithotripsy, were analyzed and categorized by three independent observers into two distinct groups: type I--crescent to disc shape with gradual attenuation of echoes, and type II--rim-shape with abrupt shadowing. The degree of fragmentation and rate of stone clearance were significantly greater for type I stones than for type II stones.