Reversibility of structural changes in the resistance vessels in hypertension: a review of studies with pindolol.

1. In recent years evidence has accumulated which indicates that although various beta-adrenoceptor antagonists are equally effective in lowering blood pressure in patients with essential hypertension the mechanisms of action of the different drugs are heterogeneous. 2.

Beta-blocking effect and pharmacokinetics of pindolol in young and elderly hypertensive patients.

The pharmacokinetics and beta-blocking effect of pindolol has been compared in 20 patients with essential hypertension (WHO Stage I), 10 below 25 years of age and 10 older than 60 years. Each patient received pindolol 10 mg p.o.

Haemodynamic effects of pindolol in essential hypertension with special reference to resistance vessels in the forearm during maximal vasodilatation.

Eleven patients, mean age 45 years, with previously untreated hypertension (WHO stage I) were treated over 16 months with pindolol in dosages of 5-30 mg/day. The effects on blood pressure and peripheral vascular resistance (PR) were studied before and after 2 and 16 months of treatment. Recordings were performed at rest, and after maximal vasodilatation obtained by ischaemic work to exhaustion with a hand-ergometer.