CAD/CAM Resin-Based Composites for Use in Long-Term Temporary Fixed Dental Prostheses.

The aim of this in vitro study was to analyse the performance of CAD/CAM resin-based composites for the fabrication of long-term temporary fixed dental prostheses (FDP) and to compare it to other commercially available alternative materials regarding its long-term stability. Four CAD/CAM materials [Structur CAD (SC), VITA CAD-Temp (CT), Grandio disc (GD), and Lava Esthetic (LE)] and two direct RBCs [(Structur 3 (S3) and LuxaCrown (LC)] were used to fabricate three-unit FDPs. 10/20 FDPs were subjected to thermal cycling and mechanical loading by chewing simulation and 10/20 FDPs were stored in distilled water.

Is Micro X-ray Computer Tomography a Suitable Non-Destructive Method for the Characterisation of Dental Materials?

The aim of the study was to investigate the effect of X-rays used in micro X-ray computer tomography (µXCT) on the mechanical performance and microstructure of a variety of dental materials. Standardised bending beams (2 × 2 × 25 mm) were forwarded to irradiation with an industrial tomograph. Using three-dimensional datasets, the porosity of the materials was quantified and flexural strength was investigated prior to and after irradiation.

Untargeted Metabolomic Analysis Combined With Multivariate Statistics Reveal Distinct Metabolic Changes in GPR40 Agonist-Treated Animals Related to Bile Acid Metabolism.

Metabolomics has been increasingly applied to biomarker discovery, as untargeted metabolic profiling represents a powerful exploratory tool for identifying causal links between biomarkers and disease phenotypes. In the present work, we used untargeted metabolomics to investigate plasma specimens of rats, dogs, and mice treated with small-molecule drugs designed for improved glycemic control of type 2 diabetes mellitus patients via activation of GPR40. The pharmacology of GPR40 is not yet fully understood.

Evaluation of the Midface by Statistical Shape Modeling.

Purpose: The aim of this investigation was to generate a statistical shape model (SSM) of the midface and evaluate symmetry, gender aspects, and bone thickness.

Methods: About 102 computed tomography scans were analyzed to create the SSM. This included segmentation, landmark attribution, and Procrustes and principal component analysis.

Computer-Aided Versus Conventional Planning in Orbital Traumatology Using Preformed Meshes: Development of a New Workflow.

Purpose: Preformed orbital meshes (POMs) are routinely used in orbital traumatology. As the shapes of commercially available POMs differ, we wanted to evaluate whether investigators would use the same POM in a given situation and perform similar virtual positioning. Furthermore, we investigated whether these tasks could be performed more quickly and more reproducibly using a new software workflow.