Publications by authors named "H Denis Alexander"

Purpose: The prevalence of obesity, along with that of its associated health conditions, including cardiovascular diseases, diabetes mellitus, and liver diseases, such as non-alcoholic fatty liver disease (NAFLD), is increasing annually. Bariatric surgery is indicated for the treatment of obesity if conservative treatment fails. While various liver fibrosis scores have been proposed for assessing liver function, they are typically used prior to bariatric surgery.

View Article and Find Full Text PDF

Objective: Robot-assisted (RA) technology is becoming more widely integrated and accepted in spine surgery. The authors sought to evaluate operative and patient-reported outcomes (PROs) in RA versus fluoroscopy-assisted (FA) pedicle screw placement during minimally invasive surgery (MIS) transforaminal lumbar interbody fusion (TLIF).

Methods: The authors retrospectively studied elective patients who underwent single- or multilevel MIS TLIF for degenerative indication using FA versus RA pedicle screw placement.

View Article and Find Full Text PDF

Meta-omics is commonly used for large-scale analyses of microbial eukaryotes, including species or taxonomic group distribution mapping, gene catalog construction, and inference on the functional roles and activities of microbial eukaryotes in situ. Here, we explore the potential pitfalls of common approaches to taxonomic annotation of protistan meta-omic datasets. We re-analyze three environmental datasets at three levels of taxonomic hierarchy in order to illustrate the crucial importance of database completeness and curation in enabling accurate environmental interpretation.

View Article and Find Full Text PDF
Article Synopsis
  • Electrical motor cortex stimulation can enhance motor function and support structural changes in the corticospinal system after injuries, with a focus on finding molecular biomarkers for this plasticity.
  • Two neuromodulation techniques were tested: repetitive multipulse stimulation (rMPS) and intermittent theta burst stimulation (iTBS), revealing that only iTBS effectively promoted corticospinal tract sprouting after short-term stimulation.
  • Key molecular changes, including mTOR activation and PTEN deactivation, were associated with significant axon growth, indicating that iTBS may be the better option for recovery after spinal cord injuries due to its effects on both structural and physiological plasticity.
View Article and Find Full Text PDF