Publications by authors named "H Demetriades"
Effect of growth hormone on colonic anastomosis after intraperitoneal administration of 5-fluorouracil, bleomycin and cisplatin: An experimental study.
World J Gastrointest Surg
August 2024
Article Synopsis
- - Growth hormone (GH) potentially enhances the healing of colonic anastomosis in rats after chemotherapy with 5-fluorouracil, bleomycin, and cisplatin, which generally impairs recovery.
- - In a study involving 80 Wistar rats, those receiving both chemotherapy and GH showed improved collagen deposition, indicated by higher hydroxyproline levels compared to those who only received chemotherapy.
- - Rats treated with GH and chemotherapy had similar body weights and bursting pressures compared to the control group, although they experienced more adhesions than untreated rats, suggesting GH might help mitigate some adverse effects of chemotherapy on wound healing.
Aim: Growth hormone is known to affect healing on the postoperative patient. The aim of the present experimental study was to evaluate the effect of systematic infusion of growth hormone on the healing of colonic anastomoses in rats.
Methods: Fourty Albino-Wistar male rats were randomly divided into two groups, a control group (CONTROL) and a growth hormone (GH) group.
Anastomotic leakage following low anterior resection for rectal cancer.
Tech Coloproctol
November 2010
Aim: Aim of this study is to present the incidence of anastomotic leakage after anterior resection for rectal cancer and to demonstrate the therapeutic approach for the treatment of this complication.
Patients And Methods: Between 1990 and 2009, 170 patients underwent low anterior resection with total mesorectal excision (TME).
Results: A total of 14 (8.