Publications by authors named "H Delfino"
Background And Aim: Although it is well established that hormones like glucagon stimulates gluconeogenesis via the PKA-mediated phosphorylation of CREB and dephosphorylation of the cAMP-regulated CREB coactivators CRTC2, the role of neural signals in the regulation of gluconeogenesis remains uncertain.
Methods And Results: Here, we characterize the noradrenergic bundle architecture in mouse liver; we show that the sympathoexcitation induced by acute cold exposure promotes hyperglycemia and upregulation of gluconeogenesis via triggering of the CREB/CRTC2 pathway. Following its induction by dephosphorylation, CRTC2 translocates to the nucleus and drives the transcription of key gluconeogenic genes.
Article Synopsis
- The study aimed to examine the link between specific Single Nucleotide Polymorphisms (SNPs) in the DRD2 and BDNF genes and Binge Eating Disorder (BED) in patients who regained weight after bariatric surgery.
- Researchers evaluated 177 bariatric surgery patients, assessing anthropometric measurements, BED using questionnaires, and genotyping relevant SNPs through real-time PCR.
- Results showed that certain allele variants (CT and TT for DRD2 rs1800497; GA and AA for BDNF rs6265) were more common in patients with BED, suggesting these genetic factors increase the risk of BED, particularly in those who have experienced weight regain.
Green tea supplementation improves oxidative stress biomarkers and modulates IL-6 circulating levels in obese women.
Nutr Hosp
July 2019
Introduction: obesity is associated with high levels of oxidative stress (OS) and inflammation. There is a lot of evidence that some polyphenols, such as green tea, have a positive impact on the OS state and consecutively, on inflammation. Objectives: the purposes of this study were: a) evaluate OS biomarkers in both obese and normal weight women; and b) evaluate if green tea supplementation has an impact on OS and inflammatory cytokine biomarkers of obese women.
View Article and Find Full Text PDFObjective: this study aimed to evaluate the association between polymorphisms of INSIG, PCSK9 and FTO genes with anthropometric, biochemical characteristics and presence of metabolic syndrome in patients with severe obesity. Material and methods: the present study enrolled 150 patients with grade II or III obesity, who were submitted to nutritional assessment, blood pressure measurement and peripheral blood collection. INSIG2 (rs75666605), PCSK9 (rs505151), and FTO (rs9939609) polymorphisms were genotyped using TaqMan Pre-Designed SNP Genotyping Assays probes in real time polymerase chain reaction (PCR).
View Article and Find Full Text PDFArticle Synopsis
- The human biological system controls food intake through a complex network of neuroendocrine signals that modulate appetite and satiety, involving various tissues, hormones, and neural circuits.
- Dysregulation of these signaling pathways can lead to eating disorders and obesity, emphasizing the importance of these mechanisms for maintaining energy balance.
- Genetic factors, particularly Single Nucleotide Polymorphisms (SNPs) in genes associated with appetite regulation and brain reward systems, play a significant role in the development of eating disorders like Binge Eating Disorder and Bulimia Nervosa.