Publications by authors named "H Darwinkel"
Article Synopsis
- The sympathetic nervous system is important for controlling innate immune responses, and its reduction in inflammatory bowel disease affects immune function in the intestines.
- Researchers examined how activation of adrenergic receptors impacts cytokine production in macrophages and studied the effects of sympathetic nerve damage in mice lacking certain immune cells.
- Results showed that nerve damage led to increased inflammation and histological damage in the intestines, indicating that the sympathetic nervous system helps regulate immune cell activity in response to microbial threats.
Neuronal control of experimental colitis occurs via sympathetic intestinal innervation.
Neurogastroenterol Motil
March 2018
Background: Vagus nerve stimulation is currently clinically evaluated as a treatment for inflammatory bowel disease. However, the mechanism by which this therapeutic intervention can have an immune-regulatory effect in colitis remains unclear. We determined the effect of intestine-specific vagotomy or intestine-specific sympathectomy of the superior mesenteric nerve (SMN) on dextran sodium sulfate (DSS)-induced colitis in mice.
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