Publications by authors named "H Dapper"
Background: Total neoadjuvant therapy (TNT) has been used for patients with locally advanced rectal cancer. The optimal sequence of chemoradiotherapy (CRT) and chemotherapy (CT) is a matter of debate.
Methods: We performed a pooled analysis of the CAO/ARO/AIO-12 and OPRA multicenter, randomized phase 2 trials to identify patient subsets that could benefit from one TNT sequence over the other regarding disease-free survival (DFS).
Article Synopsis
- Cervical fibrosis (CF) significantly affects the quality of life and functionality of head and neck cancer patients post-radiotherapy, as it leads to tissue hardening.
- A study involving 16 treated patients and 16 matched controls assessed tissue stiffness using shear wave elastography, focusing on the sternocleidomastoid muscle and nearby structures.
- Results showed that treated patients had higher tissue stiffness across all types, particularly in muscle, but maintained normal cervical range of motion, indicating a complex relationship between radiation effects, aging, and tissue characteristics.
Article Synopsis
- The study investigates how variations in the skin microbiome can affect the severity of radiation dermatitis in breast cancer patients receiving adjuvant radiotherapy.
- The research involved 20 women who underwent a comprehensive analysis of their skin microbiome before, during, and after a 7-week radiotherapy treatment.
- Findings indicated that low levels of certain healthy skin bacteria at the start of treatment were linked to more severe dermatitis, highlighting the potential role of the microbiome in skin reactions to radiation therapy.
Relevance of tumor boards for the inclusion of patients in oncological clinical trials.
J Cancer Res Clin Oncol
August 2023
Introduction: Major national and international oncological societies generally recommend treating a significant proportion of oncological patients in clinical trials to improve therapy strategies for cancer patients. At cancer centers, the recommendation about the appropriate therapy for the individual tumor patient is usually made in interdisciplinary case discussions in multidisciplinary tumor boards (MDT). In this study, we examined the impact of MDTs for the inclusion of patients in therapy trials.
View Article and Find Full Text PDFBackground: Soft tissue sarcomas (STS) are a relatively rare group of malignant tumors. Currently, there is very little published clinical data, especially in the context of curative multimodal therapy with image-guided, conformal, intensity-modulated radiotherapy.
Methods: Patients who received preoperative or postoperative intensity-modulated radiotherapy for STS of the extremities or trunk with curative intent were included in this single centre retrospective analysis.