Publications by authors named "H D Vrijmoeth"
Article Synopsis
- * Researchers analyzed cytokine production before and after antibiotic treatment in over 1,000 patients, discovering a negative relationship between antibody production and IL-10 levels, as well as increased IL-1Ra in those with advanced disease.
- * Genome-wide mapping identified 34 cytokine quantitative trait loci (cQTLs), including 31 new ones, linking immune responses to Lyme borreliosis susceptibility and offering insights relevant to other immune-related diseases.
Article Synopsis
- Genetic variation affects how individuals respond to infections, influencing both susceptibility and symptoms of diseases like Lyme borreliosis (LB).
- The study involved genome-wide association studies of 1,138 LB patients and healthy controls, evaluating genetic variants, cytokine responses, and antibody production related to the disease.
- A newly identified genetic variant, rs1061632, was linked to increased susceptibility to LB and associated with immune response alterations, highlighting the genetic factors influencing LB susceptibility and bacterial clearance.
Objectives: To describe the course of symptoms reported by patients with symptoms attributed to Lyme borreliosis (LB) without being subsequently diagnosed with LB.
Methods: We performed a prospective cohort study with patients presenting at the outpatient clinic of two clinical LB centres. The primary outcome was the prevalence of persistent symptoms, which were defined as clinically relevant fatigue (CIS, subscale fatigue), pain (SF-36, subscale bodily pain), and cognitive impairment (CFQ) for ≥ 6 months and onset < 6 months over the first year of follow-up.
Background: Patients treated for Lyme borreliosis (LB) frequently report persistent symptoms. Little is known about risk factors and etiology.
Methods: In a prospective observational cohort study with a follow-up of one year, we assessed a range of microbiological, immunological, genetic, clinical, functional, epidemiological, psychosocial and cognitive-behavioral variables as determinants of persistent symptoms after treatment for LB.
Objective: The diagnosis of Lyme borreliosis is based on two-tier testing using an ELISA and Western blot. About 5-10% of patients report persistent symptoms of unknown etiology after treatment, resulting in substantial difficulties in further diagnostic workup. This paper presents a study aimed at determining whether serology can differentiate between patients with persistent symptoms attributed to Lyme and other patients with Lyme borreliosis.
View Article and Find Full Text PDF