[Simultaneous Quadruple Therapy In The Treatment Of Helicobacter Pylori During Peptic Ulcer Disease].

Unlabelled: Helicobacter pylori (Hp) infection plays an important role in the genesis of peptic ulcer disease. In the absence of susceptibility testing, concomitant quadruple therapy is one of the most widely used eradication methods. In the absence of a study on four-drug therapy and the difficulty of studying antibiotic susceptibility in our context, we initiated this work in order to evaluate the efficacy of an empirical treatment with concomitant four-drug therapy currently available.

A model for supporting biomedical and public health researcher use of publicly available All of Us data at Historically Black Colleges and Universities.

Purpose: The aim of this study was to describe opportunities and challenges associated with the development and implementation of a program for supporting researchers underrepresented in biomedical research.

Approach: We describe a case study of the All of Us Researcher Academy supported by the National Institutes of Health (NIH), including feedback from participants, instructors, and coaches.

Findings: Lessons include the importance of inviting role models into learning networks, establishing and maintaining trusted relationships, and making coaches available for technical questions from researcher participants.

[Internal Hemorroïd Disease In Digestive Endoscopy Center Of Chu Gabriel Toure Of Bamako].

Unlabelled: the goal of this study was to investigate the internal hemorroid disease in our endoscopic center.

Method: This transversal study went from December 2011 to December 2012.

Results: Sixty cases of internal hemorroid desease were enroled with36 men and 24 women and a middle age of 47 ±14.

CDK Inhibition Primes for Anti-PD-L1 Treatment in Triple-Negative Breast Cancer Models.

Triple-negative breast cancers (TNBC) expressing PD-L1 qualify for checkpoint inhibitor immunotherapy. Cyclin E/CDK2 is a potential target axis in TNBC; however, small-molecule drugs at efficacious doses may be associated with toxicity, and treatment alongside immunotherapy requires investigation. We evaluated CDK inhibition at suboptimal levels and its anti-tumor and immunomodulatory effects.