Therapeutic Potential of Rosmarinic Acid in Tramadol-Induced Hepatorenal Toxicity: Modulation of Oxidative Stress, Inflammation, RAGE/NLRP3, ER Stress, Apoptosis, and Tissue Functions Parameters.

Aim: Tramadol (TRM), a widely used opioid analgesic for moderate to severe pain, is associated with liver and kidney toxicity at high doses or prolonged use. This study investigates the protective role of rosmarinic acid (RA), a natural phenolic compound known for its antioxidant, anti-inflammatory, and cell-protective properties, against TRM-induced hepatorenal toxicity.

Methods: Thirty-five male Wistar rats were divided into five groups: Control, TRM, RA, TRM+RA25, and TRM+RA50.

Assessment of MPOX infection-related knowledge levels, concerns, and associated factors: a community-based cross-sectional study.

Background: MPOX (Monkeypox) is a zoonotic disease of increasing global concern due to its re-emergence and potential for human-to-human transmission. Effective public health interventions rely on understanding socio-demographic determinants of knowledge and perceptions of the disease. This study aimed to investigate MPOX-related knowledge and concerns among a diverse sample in Türkiye, identifying key factors influencing knowledge levels.

Investigation of the Effects of Silymarin on Ovarian Ischemia Reperfusion via Nrf-2/HO-1/NQO1, Ki-67 and Wnt Signaling Pathways.

Ovarian ischemia is a pathological condition that usually occurs due to ovarian torsion, resulting in the interruption of blood supply to the ovaries and oxygen deficiency. Silymarin (SLM) is a flavonoid complex of plant origin with pharmacological properties such as antioxidant, anti-inflammatory, and antiapoptotic effects. In this study, we investigated the effects of SLM through different pathways in rats subjected to experimental ovarian ischemia/reperfusion (I/R).

Evaluation Of Maternal And Fetal Findings In Patients With Pemphigoid Gestationis.

Objective: To evaluate the maternal and fetal outcomes of 12 pregnant women diagnosed with pemphigoid gestationis, in conjunction with a review of the literature.

Methods: A retrospective review was conducted on the medical records of 12 patients diagnosed with pemphigoid gestationis who presented  between January 2014 and January 2024.

Results: Twelve pregnant patients with pemphigoid gestationis were included in the study.

Diagnostic accuracy analysis of SARC-F, its modified versions and the Quality of Life in Sarcopenia questionnaire in screening for sarcopenia in nursing home residents.

Aim: Sarcopenia, which is among the most important geriatric syndromes, is also a public health challenge. This study evaluated the performance of the SARC-F, its modified versions and the Quality of Life in Sarcopenia (SarQoL) in screening for sarcopenia.

Methods: In the diagnostic accuracy study carried out with a total of 195 nursing home residents, sarcopenia was evaluated according to the European Working Group on Sarcopenia in Older Persons 2 algorithm.