Improvement of a woman's alcohol-related dementia via off-label memantine treatment: a 16-month clinical observation.

Objective: To report a case of long-term treatment of moderate alcohol-related dementia (ARD) with memantine.

Case Summary: We present the case of a 48-year-old German woman with a long history of alcohol dependence and cognitive impairments, who was diagnosed with moderate ARD (according to ICD-10 criteria) after having ruled out other dementias. Her cognitive functioning improved with off-label use of memantine (up to 20 mg/d) under abstinent conditions.