Publications by authors named "H D Durham"
Proteostasis is maintained through regulated protein synthesis and degradation and chaperone-assisted protein folding. However, this is challenging in neuronal projections because of their polarized morphology and constant synaptic proteome remodeling. Using high-resolution fluorescence microscopy, we discover that hippocampal and spinal cord motor neurons of mouse and human origin localize a subset of chaperone mRNAs to their dendrites and use microtubule-based transport to increase this asymmetric localization following proteotoxic stress.
View Article and Find Full Text PDFExamining Sociodemographic Variability in the Amount and Type of Interventions for Children With Autism.
Am J Intellect Dev Disabil
November 2024
Various intervention usage is associated with positive outcomes for children with autism. However, the intensity of these interventions tends to be below recommendations, especially for minoritized children. This study aimed to examine how average weekly intervention hours among children vary by sociodemographic factors.
View Article and Find Full Text PDFReversal of cognitive deficits in FUS amyotrophic lateral sclerosis mice by arimoclomol and a class I histone deacetylase inhibitor independent of heat shock protein induction.
Neurotherapeutics
September 2024
Article Synopsis
- Protein misfolding and mislocalization are key issues in both familial and sporadic ALS, making the maintenance of protein balance through heat shock proteins (HSPs) an important treatment strategy, but neurons have a high threshold for this response.
- In experiments with mouse models of ALS, the drugs arimoclomol and RGFP963 showed mixed results: they didn't increase HSP expression in FUS mice but helped improve cognitive function and dendritic spine density.
- In SOD1 mice, some HSPs were upregulated in muscle but not in spinal cord, with drug treatments enhancing muscle performance without promoting HSP expression, suggesting alternate
Article Synopsis
- * This study analyzed the expression of two specific HSPs, HSPA1A and HSPA8, in cultured motor neurons with ALS-linked variants (TDP-43, FUS, SOD1), finding poor induction of HSPA1A and lowered levels of HSPA8, which hampers protective chaperoning.
- * Treatments with histone deacetylase inhibitors proved more effective than the HSP coinducer arimoclomol in boosting HSP expression and ensuring neuronal health,
Proteostasis is maintained through regulated protein synthesis and degradation and chaperone-assisted protein folding. However, this is challenging in neuronal projections because of their polarized morphology and constant synaptic proteome remodeling. Using high-resolution fluorescence microscopy, we discovered that neurons localize a subset of chaperone mRNAs to their dendrites and use microtubule-based transport to increase this asymmetric localization following proteotoxic stress.
View Article and Find Full Text PDF