Publications by authors named "H D Boldt"
Introduction: Choroidal metastases from systemic malignancies are the most common intraocular malignancies in adults. External beam radiation (EBR) has historically been first-line therapy for metastatic tumors to the choroid. However, good responses have been described with newer targeted biologics.
View Article and Find Full Text PDFMeningiomas are the most common primary central nervous system tumor. Clinical trials have failed to support effective medical treatments, despite initially promising animal studies. A key issue could be that available experimental models fail to mimic the clinical situation.
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- Aggressive pituitary neuroendocrine tumors (PitNETs) often grow despite treatment and can metastasize, making them particularly challenging to manage.
- This study analyzed tumor samples from 64 patients to investigate genetic markers, finding distinct patterns between aggressive/metastatic tumors and benign ones through genome-wide methylation and chromosomal analyses.
- The results indicate potential biomarkers that could help in identifying high-risk patients earlier, refining treatment protocols, and improving outcomes for those with aggressive pituitary tumors.
Article Synopsis
- The study aimed to evaluate how accurately B-scan ultrasonography detects vitreoretinal issues after open-globe injury (OGI) repair, using findings from later surgeries as a reference.
- Researchers analyzed 62 eyes from 61 patients at the University of Iowa Hospitals and Clinics over a five-year period, focusing on various vitreoretinal conditions like vitreous hemorrhage and retinal detachment.
- Results showed that while B-scan was good at identifying vitreous hemorrhage, it had significant limitations in diagnosing other issues, indicating that it should not be solely relied upon for detecting serious pathologies.