Publications by authors named "H Cross"
Spatial transcriptomics promises to transform our understanding of tissue biology by molecularly profiling individual cells . A fundamental question they allow us to ask is how nearby cells orchestrate their gene expression. To investigate this, we introduce cross-expression, a novel framework for discovering gene pairs that coordinate their expression across neighboring cells.
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- N-of-1 trials are single-patient studies that focus on individual responses to treatments, particularly useful for patients with rare forms of epilepsy where larger clinical trials are hard to conduct.
- A systematic review analyzed such trials to evaluate their design, outcomes, and biases, revealing strong individual treatment customization but also some reporting limitations.
- The findings highlight the potential of N-of-1 trials to provide valuable insights for treating epilepsy, suggesting a need for improved reporting and methodology in future studies.
Article Synopsis
- The study investigates the link between Onchocerca volvulus (causing onchocerciasis) and epilepsy in Mahenge, Tanzania, focusing on the prevalence of both conditions after 25 years of ivermectin treatment.
- A cross-sectional survey of 56,604 individuals was conducted, revealing onchocerciasis prevalence among children at 11.8%, higher in medium-altitude villages, and epilepsy incidence at 21.1 cases per 1,000 persons, also more prevalent in medium altitudes.
- Female gender, middle altitudes, and positive OV16 antibodies were associated with a higher likelihood of having epilepsy, highlighting ongoing public health challenges despite long-term ivermectin use.
Purpose: Hearing loss is highly prevalent in long-term care home (LTCH) residents with dementia ("residents") and exacerbates confusion and communication difficulties. Residents rely on caregivers, including family, for hearing-related care. This study aims to understand the drivers of family caregivers' provision of hearing support to LTCH residents using the Behaviour Change Wheel.
View Article and Find Full Text PDFSoil microbiomes are heterogeneous, complex microbial communities. Metagenomic analysis is generating vast amounts of data, creating immense challenges in sequence assembly and analysis. Although advances in technology have resulted in the ability to easily collect large amounts of sequence data, soil samples containing thousands of unique taxa are often poorly characterized.
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