Bilateral phacoemulsification and intraocular lens implantation in a pet rabbit with cataracts.

Background: The occurrence of cataracts in rabbits is a common reason for consultation in veterinary ophthalmology.

Case Description: A 6-year-old female Lop rabbit () was referred with a 3-month history of bilateral cataracts. The owner noted that the rabbit was frequently bumping into obstacles.

ADAM interact with large protein complexes to regulate Histone modification, gene expression and splicing.

Cranial neural crest (CNC) cells are key stem cells that contribute to most of the facial structures in vertebrates. ADAM ( A D isintegrin A nd M etalloprotease) proteins are essential for the induction and migration of the CNC. We have shown that Adam13 associates with the transcription factor Arid3a to regulate gene expression.

Making waves: Promoting municipal water reuse without a prevailing scarcity driver.

The wealth of water reuse research in scarcity and/or rapid urbanisation contexts has underpinned significant change in many relatively water scarce contexts. Less progress has been achieved in water rich contexts; a fact illustrated by the lack of change on the ground. The Climate Emergency demands that all municipalities urgently contribute to more efficient resource management of water.

Bop1 is required to establish precursor domains of craniofacial tissues.

Bop1 can promote cell proliferation and is a component of the Pes1-Bop1-WDR12 (PeBoW) complex that regulates ribosomal RNA processing and biogenesis. In embryos, however, bop1 mRNA is highly enriched in the neural plate, cranial neural crest and placodes, and potentially may interact with Six1, which also is expressed in these tissues. Recent work demonstrated that during development, Bop1 is required for establishing the size of the tadpole brain, retina and cranial cartilages, as well as controlling neural tissue gene expression levels.

Zmym4 is required for early cranial gene expression and craniofacial cartilage formation.

The Six1 transcription factor plays important roles in the development of cranial sensory organs, and point mutations underlie craniofacial birth defects. Because Six1's transcriptional activity can be modulated by interacting proteins, we previously screened for candidate interactors and identified zinc-finger MYM-containing protein 4 (Zmym4) by its inclusion of a few domains with a cofactor, Sine oculis binding protein (Sobp). Although Zmym4 has been implicated in regulating early brain development and certain cancers, its role in craniofacial development has not previously been described.