[Computer-assisted mechanical ventilation of newborn infants].

Mechanical ventilation of mature or premature newborns is supposed to provide pulmonary gas exchange while causing minimal side effects to the respiratory system and circulation of the infants. A certain degree of alveolar ventilation, for example, can be achieved by different ventilator settings with different airway pressures (Fig. 1), and thus the corresponding effects on lung mechanics, barotrauma, and circulation differ.

Structural changes of hair after incorporation of the proline analogue L-azetidine-2-carboxylic acid. A model of hair disease by alteration of primary structure.

In order to correlate biochemical changes of the hair with physical properties we present a model for the examination techniques. L-azetidine was incorporated into the hair keratin complex and the resulting mechanoelastic properties were determined using the ultramicrohardness testing system on scanning electron microscopy. Structure was investigated by X-ray diffraction and incorporation of L-azetidine was detected by thin-layer chromatography.

[Toxoplasmosis screening of pregnant patients in Austria].

The frequency of congenital Toxoplasma infection is strictly correlated with the frequency of Toxoplasma primary infection in child bearing age. The latter corresponds directly to the increase of contamination rate in the normal population between 20 and 40 years of age, if determined with a sensitive method detecting also low antibody concentrations with certainty (Sabin-Feldman-dye test). In four representative studies the relation was 0.

[Incorporation of L-azetidine-2-carboxylic acid into collagen of the skin. Structural changes].

As previously shown by two dimensional thin-layer chromatography L-azetidine-2-carboxylic-acid (L-Az) is incorporated into type I skin collagen instead of proline when 3 week old mice are fed with a 0,1% solution of L-Az orally. Ultrastructural investigations did not reveal significant changes in collagen periodicity and on fibril diameter. The collagen fibrils of the upper papillary dermis seemed to be packed more densely, sometimes only one electron dense lamina was seen instead of basal lamina and plasma membrane.

Determination of glucitollysine for the quantitation of non-enzymatic glucosylation by ion exchange chromatography and reverse phase liquid chromatography.

A specific and sensitive method for the quantitative determination of the stable, reduced glucose-lysine adduct, glucitollysine (GL), in plasma protein samples is described. The method uses standard amino acid ion exchange chromatography followed by reverse phase high performance liquid chromatography after derivatisation of GL to a fluorescent product. Moreover, GL was characterised and identified in plasma samples by means of mass spectroscopy.