Publications by authors named "H Colhoun"
Article Synopsis
- The study explores how a history of mental disorders, especially PTSD, influences the severity of PTSD symptoms in people affected by earthquakes, highlighting the need for better understanding in treatment.
- Researchers compared individuals with prior mental disorders to those without and found that those with any past mental issues tend to experience more current psychological disorders.
- The results indicate that while prior PTSD patients faced more life challenges, the presence of any previous mental disorder doesn't necessarily lead to more severe PTSD, suggesting the importance of screening for all trauma survivors, regardless of their mental health history.
Background: GLP-1 receptor agonists reduce the risk of major adverse cardiovascular events (MACE) and can also have kidney benefits. However, whether GLP-1 receptor agonists improve clinically important kidney outcomes remains uncertain. We aimed to comprehensively assess the effects of GLP-1 receptor agonists on kidney and cardiovascular disease outcomes by performing a meta-analysis of randomised controlled trials.
View Article and Find Full Text PDFIdentified genetic loci for C-peptide and age at diagnosis (AAD) in individuals with type 1 diabetes (T1D) explain only a small proportion of their variation. Here, we aimed to perform large metagenome-wide association studies (GWAS) of C-peptide and AAD in T1D; and to identify the HLA allele/haplotypes associated with C-peptide and AAD. 7,252 and 7,923 European individuals with T1D were included in C-peptide and AAD GWAS, respectively.
View Article and Find Full Text PDFBackground: Population-based incidence data on young-adult-onset type 1 diabetes and type 2 diabetes are limited. We aimed to examine secular trends in the incidence of diagnosed type 1 diabetes and type 2 diabetes with an age of onset between 15 and 39 years.
Methods: In this multicountry aggregate data analysis, we assembled eight administrative datasets from high-income jurisdictions and countries (Australia, Denmark, Finland, Hungary, Japan, Scotland, South Korea, and Spain [Catalonia]) that had appropriate data available from an international diabetes consortium (GLOBODIAB) describing incidence by diabetes type among people aged 15-39 years from 2000 to 2020.
Article Synopsis
- Current guidelines advise against metformin for patients with advanced kidney impairment, despite limited evidence supporting this recommendation, prompting an observational study to compare outcomes of continuing versus stopping metformin after developing stage 4 chronic kidney disease (CKD).
- The study found that out of 4,278 metformin users with incident CKD stage 4, those who stopped taking the medication experienced a significantly lower 3-year survival rate compared to those who continued, although the incidence of major cardiovascular events was similar between the two groups.
- The findings suggest that ongoing metformin use may be beneficial for patients with advanced kidney impairment, although the study does acknowledge potential limitations due to residual confounding factors.