Publications by authors named "H Chinchinian"
Article Synopsis
- Early detection of cell type changes in genitourinary tract diseases is a clinical challenge, as current assays often lack the detailed cellular insight that invasive biopsies provide.
- Researchers studied cell-free RNA (cfRNA) from urine samples of healthy individuals and kidney stone patients, aiming to improve understanding of cell type contributions and the urine metabolome.
- The analysis revealed that urine transcriptome can discern contributions from various cell types and highlighted specific metabolic pathways linked to kidney function, indicating noninvasive urine analysis could serve as a useful tool in diagnosing related diseases.
Urine is assayed alongside blood in medicine, yet current clinical diagnostic tests utilize only a small fraction of its total biomolecular repertoire, potentially foregoing high-resolution insights into human health and disease. In this work, we characterized the joint landscapes of transcriptomic and metabolomic signals in human urine. We also compared the urine transcriptome to plasma cell-free RNA, identifying a distinct cell type repertoire and enrichment for metabolic signal.
View Article and Find Full Text PDFA rare instance of renal cell carcinoma metastatic to the prostate gland is described. The prostatic metastases caused acute urinary retention and were clinically thought to represent benign prostatic hypertrophy. Histologic examination of the transurethral resection specimen demonstrated the true nature of the tumor.
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