Publications by authors named "H Chardin"
Since the introduction of efficient anti-SARS-CoV-2 vaccines, the detection of antibodies becomes useful for immunological monitoring and COVID-19 control. Therefore, this longitudinal study aimed to evaluate the detection of SARS-CoV-2 antibodies in the serum and saliva of COVID-19-vaccinated adults. The study included 13 not vaccinated and 35 vaccinated participants with two doses of CoronaVac (Sinovac/Butantan) vaccine who subsequently received BNT162b2 (Pfizer-BioNTech) vaccine as a booster dose.
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- The study focuses on the lack of research connecting salivary metabolomics to biomarkers for Sjögren's syndrome (SS).
- The research involved analyzing saliva samples from 18 female SS patients and 22 healthy controls using advanced mass spectrometry, revealing 91 metabolites with different levels in these groups.
- Out of these, 16 metabolites were confirmed as significant, with alanine, isovaleric acid, and succinic acid showing strong potential as biomarkers due to their high sensitivity and specificity, indicating they could help in developing a salivary diagnostic test for SS.
Despite the growing interest in salivary metabolomics, few studies have investigated the impact of aging on the salivary metabolome. The alterations in metabolic pathways that occur with aging are likely to be observed in pathologies affecting older people and may interfere with the search for salivary biomarkers. It is therefore important to investigate the age-related changes occurring in the salivary metabolome.
View Article and Find Full Text PDFUnlabelled: Since the introduction of efficient vaccines anti-SARS-CoV-2, antibody quantification becomes increasingly useful for immunological monitoring and COVID-19 control. In several situations, saliva samples may be an alternative to the serological test. Thus, this rapid systematic review aimed to evaluate if saliva is suitable for SARS-CoV-2 detection after vaccination.
View Article and Find Full Text PDFAdvances in metabolomics have allowed the identification and characterization of saliva metabolites that can be used as biomarkers. However, discrepancies can be noted with the content of the same biomarker being increased or decreased for a given disease. Differences in the way saliva is collected, stored, and/or treated could cause these discrepancies.
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