Publications by authors named "H Chang-Quan"
Article Synopsis
- The study examined the association between the ARNTL2 (BMAL2) gene polymorphism rs2306074 T/C and the risk of developing Alzheimer’s disease (AD) in a Chinese population.
- Researchers analyzed data from 296 AD patients and 423 control subjects, finding that C carriers had a higher prevalence in AD patients compared to controls, particularly in those who do not carry the APOE ε 4 allele.
- Results indicated that while C carriers and those with CC genotypes show increased susceptibility to AD among APOE ε 4 non-carriers, this association does not hold for APOE ε 4 carriers.
Objective: Cigarette smoking has been confirmed as a factor influencing arterial blood pressure. In the present study, we studied whether cigarette smoking habits were still associated with arterial blood pressure among Chinese nonagenarians/centenarians.
Methods: The present study analyzed data from a survey conducted on all residents aged 90 years or more in the DuJiangYan district (in total 2,311,709 inhabitants) in 2005.
Objectives: In the present study, it was examined whether polymorphism of circadian locomotor output cycle kaput (CLOCK) gene 3111T/C was associated with susceptibility of Alzheimer disease (AD).
Methods: This study was conducted using a case-control method. Genotypes of apolipoprotein E (APOE e4) and CLOCK gene 3111T/C were determined by restriction fragment length polymorphism method and TaqMan assay method, respectively.
In this study, we examined the association of fasting serum insulin (FSI) and fasting serum glucose (FSG) with cognitive impairment in the very elderly using a sample of Chinese nonagenarians/centenarians. This study used data from a survey that was conducted in 2005 on all residents aged 90 years or more in a district with 2,311,709 inhabitants. FSG, FSI, and cognitive function were analyzed.
View Article and Find Full Text PDFObjective: We observed the function of hypothalamic-pituitary-thyroid axis in patients with Alzheimer disease (AD) using a case-control study.
Methods: The case was a cohort that included 50 patients with AD. For each case subject, 1 control who was of similar age, sex, daily activities (scale of Lawton), sleep quality (Pittsburgh Sleep Quality Index), and depression (15-item Geriatrics Depression Scale) was recruited.