S-glutathionylation (SSG) is increasingly recognized as a critical signaling mechanism in the heart, yet SSG modifications in cardiac sarcomeric proteins remain understudied. Here we identified SSG of the ventricular isoform of myosin light chain 1 (MLC-1v) in human, swine, and mouse cardiac tissues using top-down mass spectrometry (MS)-based proteomics. Our results enabled the accurate identification, quantification, and site-specific localization of SSG in MLC-1v across different species.
View Article and Find Full Text PDFAnxiety experienced when interacting in a foreign language hinders communication through detrimental behavioral, cognitive, and somatic effects. Despite its impact, there is limited research on how neural asymmetry relates to foreign language anxiety (FLA). While researchers have investigated FLA through brain imaging, there remains an absence of studies examining its correlation with frontal alpha asymmetry.
View Article and Find Full Text PDFThe nasal airway comprises a complex network of passages and chambers and plays an important role in regulating the respiratory system's functions. The nasal vestibule is the first chamber of the nasal airway. While variations in nasal vestibule geometries are known to exist between humans, details of their implications on how they may affect the efficacy of nasal drug delivery devices are less clear.
View Article and Find Full Text PDFPurpose: To develop and pilot-test a novel training programme for nurses in acute care settings to improve their decision-making support skills, knowledge, attitudes, and confidence in conducting advance care planning (ACP).
Methods: A single-group repeated measures design was employed. This study was conducted in two phases.