Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphisms.

In this study the GSTmu phenotype and ADH genotype at the ADH3 locus were investigated in a group of 39 alcoholic men with upper respiratory/digestive tract cancer: 21 with oropharyngeal cancer and 18 with laryngeal cancer. The results are compared with those of a control group of 37 alcoholic men without alcohol-related medical complications. Of the control subjects, 48% were found to be GSTmu deficient [GSTmu(-)] and 19% carried the ADH(3)1/ADH(3)1 genotype.

[Acute necrotizing sialometaplasia of the parotid gland].

Parotidean localization of acute necrotizing sialometaplasia is exceptional. Based on one observation, the authors evoke the diagnostic and physiopathological problems raised by this localization. The association of facial paralysis and a parotidean tumor make the case presented interesting, leading to exploratory surgery which can alone provide a diagnosis.

[Treatment of subglottic stenoses using the Pearson's operation: apropos of 3 cases].

Surgery of stenoses of the laryngo-tracheal junction is governed by the necessity of maintaining the support of the cricoid-arytenoid articulations and of preserving the recurrent nerves. Sub-total cricoid resection with conservation of the recurrent nerves, known as Pearson's operation, enables the treatment of fixed sub-glottic stenoses with mobile larynx. On the basis of three recent observations, the authors define the indications and the performance of this surgery.