Publications by authors named "H Cederberg"
Article Synopsis
- The study examines genetic regulation of mRNA, proteins, and metabolites in blood samples from over 3,000 people, revealing that many genetic variants influence multiple molecular traits.* -
- It finds that there's a strong genetic connection between gene expression and protein levels (66.6%), and shows broad connections across various tissues, highlighting the shared genetic basis for different traits.* -
- By creating networks of known genetic variants, the research indicates that these variants are more frequently linked to gene expression rather than other molecular traits, helping to clarify the mechanisms behind genetic associations.*
Aims: We describe a 22-year prospective observational population-based study that determined the prevalence and incidence of type 2 diabetes (T2D) and intermediate hyperglycaemia (IH), obesity, hypertension, and disorders of lipid metabolism in a middle-age population in the Finnish municipality of Savitaipale.
Methods: 1151 people participated in the baseline survey in 1996-1999, following two follow-up examinations, in 2007-2008 and 2018-2019. Follow-up studies comprised clinical measurements, 2-h oral glucose tolerance test and other biochemistry, questionnaires, and registry data.
Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants ( = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 months. HbA was also measured.
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- The study examines transcriptomic signatures related to type 2 diabetes (T2D) in blood to better understand metabolic dysfunction and the inflammatory role in insulin resistance.
- Researchers analyzed gene co-expression in blood samples from individuals with and without T2D, identifying 55 co-expression modules that show links to insulin action and glucose tolerance.
- The findings suggest significant associations between certain gene modules, especially those related to immune cells, and clinical traits of T2D, aiming to provide a comprehensive insight into blood's molecular regulation and its relevance to diabetes.
Context: Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-scale studies looking at the genetic determinants of beta-cell glucose sensitivity.
Objective: To understand the genetic determinants of pancreatic beta-cell glucose sensitivity using genome-wide meta-analysis and candidate gene studies.