Association of Vitiligo With Tumor Response in Patients With Metastatic Melanoma Treated With Pembrolizumab.

Importance: Vitiligo is an autoimmune skin disorder that reacts against melanocytes. The association of vitiligo with tumor response in patients with melanoma who undergo immunotherapy has been reported but is still controversial.

Objective: To prospectively evaluate the appearance of vitiligo in patients receiving pembrolizumab, a monoclonal antibody directed against the programmed death cell receptor.

Genital and anorectal mucosal melanoma is associated with cutaneous melanoma in patients and in families.

Background: Genital and anorectal mucosal melanomas (GAMMs) are rare compared with cutaneous melanoma (CM). Many epidemiological and genetic studies have been carried out on CM. In contrast, the genetic and environmental risk factors for GAMM have been poorly documented up to now.

[Eclampsia: 8-year experience].

Eighty-one cases of eclampsia were managed from april 1985 to may 1993 with an incidence of 1.0 in 1.000 deliveries, at the Department of Obstetric, Gynecology and Neonatology of Barros Luco-Trudeau Hospital, Santiago, Chile.

[Eclampsia at the Rancagua Regional Hospital].

Forty-four cases of eclampsia with an incidence of 2.3 in 1,000 deliveries were analyzed. The major frequency was in primiparas (81.