Publications by authors named "H Carrara"
Article Synopsis
- - The study aimed to find specific microRNAs (miRNAs) and their mRNA targets that influence how well patients with advanced invasive ductal carcinoma respond to chemotherapy.
- - Researchers compared miRNA expression in patients who responded positively to treatment versus those who did not, utilizing data from The Cancer Genome Atlas (TCGA) for deeper analysis.
- - A predictive model based on 24 differentially expressed miRNAs was developed, revealing key miRNAs linked to chemotherapy success, and proposed further exploration to validate these findings.
Objective: Neoadjuvant chemotherapy (NACT) has become the standard of care for patients with triple-negative breast cancer (TNBC) with tumors > 1 cm or positive axillary nodes. Pathologic complete response (pCR) has been used as an endpoint to select patients for treatment scaling. This study aimed to examine the benefit of adding adjuvant capecitabine for TNBC patients who did not achieve pCR after standard NACT in a real-world scenario.
View Article and Find Full Text PDFObjectives: The COVID-19 pandemic has had a significant global impact since its declaration in March 2020. The COVID-19 pandemic has disproportionately impacted cancer patients, particularly those with breast cancer. This study aims to analyze the effects of the pandemic on women diagnosed with breast cancer recurrence.
View Article and Find Full Text PDFValidation of the online PREDICT tool in a cohort of early breast cancer in Brazil.
Braz J Med Biol Res
November 2022
PREDICT is a tool designed to estimate the benefits of adjuvant therapy and the overall survival of women with early breast cancer. The model uses clinical, histological, and immunohistochemical variables. This study aimed to evaluate the model's performance in a Brazilian population.
View Article and Find Full Text PDFEffects of non-surgical periodontal therapy on the cytokine profile in gingival crevicular fluid of breast cancer patients with periodontitis undergoing chemotherapy.
Support Care Cancer
December 2021
Objective: This study evaluated the effect of non-surgical periodontal therapy (NSPT) on the cytokine profile in gingival crevicular fluid (GCF) in patients with breast cancer and periodontitis.
Methods: Forty patients were allocated into the periodontitis group (P) (n = 20) and breast cancer with periodontitis group (BC/P) (n = 20). Two days before the removal of infectious foci from the oral cavity and NSPT, as well as periodontal reevaluations, C-reactive protein, neutrophils (10μL), and platelets (10μL), were evaluated.