Publications by authors named "H COHN"
Article Synopsis
- The study explores how vaccines specifically designed for the Omicron XBB.1.5 variant can generate effective B-cell responses, focusing on the antibody responses in individuals who received a monovalent vaccine.
- Researchers analyzed immune responses from 603 plasmablasts, expressing 100 human monoclonal antibodies to assess their effectiveness against various SARS-CoV-2 variants.
- Two specific monoclonal antibodies, M2 and M39, were identified; M2 targeted only XBB.1.5 while M39 could neutralize both XBB.1.5 and JN.1, highlighting the functional potential of variant-specific vaccines.
Article Synopsis
- Therapeutic monoclonal antibodies (mAbs), specifically bamlanivimab targeting the SARS-CoV-2 spike protein, have been shown to alter the memory B cell (MBC) responses in individuals already infected with the virus.
- The treatment skewed MBCs to favor non-receptor binding domain (RBD) epitopes, resulting in a weaker affinity for RBD memory B cells compared to those who received a placebo.
- Even after mRNA COVID-19 vaccination, these changes persisted, indicating that mAb treatment can have lasting effects on immune memory and how the immune system recognizes specific viral epitopes.
Background: Monkeypox virus has recently infected more than 88 000 people, raising concerns about our preparedness against this emerging viral pathogen. Licensed and approved for mpox, the JYNNEOS vaccine has fewer side-effects than previous smallpox vaccines and has shown immunogenicity against monkeypox in animal models. This study aims to elucidate human immune responses to JYNNEOS vaccination compared with mpox-induced immunity.
View Article and Find Full Text PDFPurpose Of Review: In type 2 diabetes (T2D) research, the phrase "attention control group" (ACGs) has been used with varying descriptions. We aimed to systematically review the variations in the design and use of ACGs for T2D studies.
Recent Findings: Twenty studies utilizing ACGs were included in the final evaluation.
Background: Although endothelial function is a marker for cardiovascular risk, endothelial dysfunction assessment is not routinely used in daily clinical practice. A growing challenge has emerged in identifying patients prone to cardiovascular events. We aim to investigate whether abnormal endothelial function may be associated with adverse 5-year outcomes in patients presenting to a chest pain unit (CPU).
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