and evaluation of the effects of condensed tannins and catechins monomers on antioxidant and intestinal health of Chinese seabass ().

Plant-derived condensed tannins (CT) exhibit strong bioactivity of antioxidant, immunostimulation and intestinal protection, but with little clues of the mechanism of action. Since CT are consist of catechins (CAs) monomers, e.g.

Tumor-derived exosomes induce neutrophil infiltration and reprogramming to promote T-cell exhaustion in hepatocellular carcinoma.

High neutrophil infiltration in hepatocellular carcinoma (HCC) is associated with a poor prognosis in patients with HCC. Tumor-derived exosomes (TDEs) have been proven to be important in the reprogramming of tumor-associated neutrophils (TANs), but the roles and mechanisms have not been fully clarified. The roles of HCC-exosome-reprogrammed neutrophils on tumor progression were evaluated in the DEN/CCl-induced HCC mouse model by blocking neutrophil infiltration, depleting neutrophil, and neutrophil adoptive transfer.

Harnessing Macrophages in Cancer Therapy: from Immune Modulators to Therapeutic Targets.

Macrophages, as the predominant phagocytes, play an essential role in pathogens defense and tissue homeostasis maintenance. In the context of cancer, tumor-associated macrophages (TAMs) have evolved into cunning actors involved in angiogenesis, cancer cell proliferation and metastasis, as well as the construction of immunosuppressive microenvironment. Once properly activated, macrophages can kill tumor cells directly through phagocytosis or attack tumor cells indirectly by stimulating innate and adaptive immunity.

Two versus three to four cycles of neoadjuvant immunochemotherapy for stage IB-IIIB non-small cell lung cancer: a real-world study.

Background: No consensus exists regarding the optimal number of cycles of neoadjuvant immunochemotherapy for patients with stage IB-IIIB non-small cell lung cancer (NSCLC). In this study, we compared the efficacy and safety of 2 cycles of neoadjuvant immunochemotherapy in stage IB-IIIB NSCLC with those of 3-4 cycles.

Methods: All patients with IB-IIIB NSCLC who received preoperative immunochemotherapy at the Department of Thoracic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, from 2019 to 2022 were consecutively included in this retrospective study.

Effect of pulmonary rehabilitation for patients with long COVID-19: a systematic review and meta-analysis of randomized controlled trials.

Background: Pulmonary rehabilitation (PR) has demonstrated efficacy in managing long COVID-19, underscoring the need to refine and tailor PR strategies for optimal patient outcomes.

Objectives: To evaluate the impact of PR on patients with long COVID-19 and to compare the efficacy of different types and durations of PR interventions.

Design: Systematic review and meta-analysis.