Optimizing natural human-derived decellularized tissue materials for periodontal bone defect repair.

Periodontal disease is a major contributor to tooth loss worldwide in adults. Particularly, periodontal bone defect is a common clinical condition, yet current therapeutic strategies exhibit limited effectiveness. Recently, natural bone graft materials have attracted considerable interest for enhancing bone defect repair due to their superior biocompatibility and osteogenic capabilities.

Identifying potential prognosis markers in relapsed multiple myeloma via integrated bioinformatics analysis and biological experiments.

Background: Almost all multiple myeloma (MM) patients will eventually develop disease that has relapsed with or become refractory to current therapeutic regimes. However, the pervious clinical parameters have been proved inaccurate for defining MM relapse, and molecular targets have become the focuses of interests. Prognostic predictions based on molecular targets have been more effective to this day.

Prescribed burning effects on carbon and nutrient cycling processes in peatlands of Greater Khingan Mountains, Northeast China.

Peatlands are significant global carbon sinks; however, their carbon storage functions are vulnerable to human activities. In the Greater Khingan Mountains of Northeast China, where forest and peatland ecosystems are interspersed extensively, prescribed burning is conducted annually on peatlands to prevent major forest fires. To investigate the effect of prescribed burning on carbon and nutrient cycling processes in peatlands, we conducted a three-year experiment in the Greater Khingan Mountains.

Effects of tannic acid on growth performance, intestinal health, and tolerance in broiler chickens.

This study investigated the optimal tannic acid dosage and assessed tolerance levels in broiler chickens. In experiment 1, 525 broilers were randomly divided into 5 treatment groups, the control group (CON group) and groups TA1 to TA4, corresponding to treatments of 0.025, 0.

Inhibition of aortic CX3CR1+ macrophages mitigates thoracic aortic aneurysm progression in Marfan syndrome in mice.

The pathogenesis of thoracic aortic aneurysm (TAA) in Marfan syndrome (MFS) is generally attributed to vascular smooth muscle cell (VSMC) pathologies. However, the role of immune cell-mediated inflammation remains elusive. Single-cell RNA sequencing identified a subset of CX3CR1+ macrophages mainly located in the intima in the aortic roots and ascending aortas of Fbn1C1041G/+ mice, further validated in MFS patients.