Preclinical Assessment of Safety and Efficacy of Deferoxamine (DFO)-pretreated Feline Adipose Mesenchymal Stem Cells.

Background/aim: This study aimed to investigate the safety and efficacy of deferoxamine (DFO) pretreated feline adipose tissue derived mesenchymal stem cells (fATMSCs) for the treatment of inflammatory disorders.

Materials And Methods: fATMSCs were isolated from feline adipose tissue and characterized using flow cytometry for surface marker expression and differentiation assays for adipogenic, osteogenic, and chondrogenic lineages. Different concentrations of DFO were used to evaluate its impact on fATMSC activity.

Electronic Structure Modulation Induced by the Synergy of Cobalt Low-Nuclearity Clusters and Mononuclear Sites for Efficient Oxygen Electrocatalysis.

The development of high-performance bifunctional single-atom catalysts for use in applications, such as zinc-air batteries, is greatly impeded by mild oxygen reduction and evolution reactions (ORR and OER). Herein, we report a bifunctional oxygen electrocatalyst designed to overcome these limitations. The catalyst consists of well-dispersed low-nuclearity Co clusters and adjacent Co single atoms over a nitrogen-doped carbon matrix (Co/NC).

Gum arabic-stabilized emulsion systems: Underlying mechanisms for enhancing storage and digestion stability of curcumin.

Although the benefits of gum arabic (GA) in developing emulsion systems are well known, the mechanism underlying its stability-enhancing effect of GA in emulsion systems stabilized with curcumin remains unclear. This study used GA-stabilized emulsion system, containing 10 wt% medium-chain triglycerides and 0.1 % curcumin.

Trends, age shifts, and potential delayed peaks post-pandemic of early-onset brain and central nervous system cancers in individuals aged 20-49: a cross-sectional study.

Background: Central nervous system (CNS) cancers are highly lethal and increasingly affect younger populations aged 20-49, posing significant challenges to global healthcare systems. Current research on early-onset CNS cancer trends is limited and outdated, with uncertain impacts from the COVID-19 pandemic. This study explores the epidemiology of early-onset CNS cancer and the pandemic's effects.

Methamphetamine and HIV-1 Tat Protein Synergistically Induce Endoplasmic Reticulum Stress to Promote TRIM13-Mediated Neuronal Autophagy.

Co-exposure to methamphetamine (METH) abuse and HIV infection exacerbates central nervous system damage. However, the underlying mechanisms of this process remain poorly understood. This study aims to explore the roles of neuronal autophagy in the synergistic damage to the central nervous system caused by METH and HIV proteins.