Publications by authors named "H C Rees"
Alopecurus aequalis is a winter annual or short-lived perennial bunchgrass which has in recent years emerged as the dominant agricultural weed of barley and wheat in certain regions of China and Japan, causing significant yield losses. Its robust tillering capacity and high fecundity, combined with the development of both target and non-target-site resistance to herbicides means it is a formidable challenge to food security. Here we report on a chromosome-scale assembly of A.
View Article and Find Full Text PDFWe profiled a large heterogenous cohort of matched diagnostic-relapse tumour tissue and paired plasma-derived cell free DNA (cfDNA) from patients with relapsed and progressive solid tumours of childhood. Tissue and cfDNA sequencing results were concordant, with a wider spectrum of mutant alleles and higher degree of intra-tumour heterogeneity captured by the latter, if sufficient circulating tumour-derived DNA (ctDNA) was present. Serial tumour sequencing identified putative drivers of relapse, with alterations in epigenetic drivers being a common feature.
View Article and Find Full Text PDFBackground: The World Health Organization has endorsed single-dose human papillomavirus (HPV) vaccination, but data on the impact on HPV prevalence in high HIV burden settings are limited.
Methods: A single-dose bivalent HPV vaccine was delivered to adolescent girls in grade 10 in a schools-based campaign in 1 district in South Africa. Impact on HPV 16 and 18 prevalence was evaluated using repeat cross-sectional surveys.
Article Synopsis
- In 2014, South Africa launched an HPV vaccination program for girls aged 9 and older, but this study focused on 17-18 year old girls who weren't vaccinated, assessing HPV prevalence and related risk factors.
- From June to December 2019, the study surveyed adolescents at primary care clinics and collected data on HPV testing, HIV status, and sexual history from 900 participants, with a focus on understanding the link between these factors and HPV detection.
- Results showed that 56.5% had high-risk HPV, with a higher prevalence in those living with HIV, underscoring the need for increased HPV vaccination efforts in populations with high HIV rates.
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