A new long acting formulation of the luteinizing hormone-releasing hormone analogue goserelin: results of studies in prostate cancer.

Purpose: To assess the pharmacodynamic equivalence of the new 10.8 mg. goserelin depot with the current 3.

A new longer-acting LHRH analog depot: preliminary results of a Dutch open phase II clinical study on a 10.8 mg Zoladex 3-monthly depot.

A new longer-acting depot formulation containing 10.8 mg Zoladex was administered subcutaneously without anesthetic to 35 patients with advanced carcinoma of the prostate. Pharmacodynamic and pharmacokinetic data show that following a transient elevation in serum LH and testosterone, the levels of both hormones decrease.

[Neurosurgical treatment of headaches].

Apart from headaches due to expanding lesions or vascular abnormalities which require a direct neurosurgical approach, some cases of untractable, acute or chronic headaches may need some neurosurgical management. Among these, "low pressure hydrocephalus" is responsible for a number of cases that can be relieved by ventriculo-atrial or ventriculo-peritoneal shunts: "dural headaches" including some atypic migraines and "cluster headaches" can be cured by sectioning of the afferent meningeal rootlet of the trigeminal nerve in its retrogasserian portion. Some occipital types of headache, "venous headache" or "strain headache", may benefit of a cross section of the occipital dura mater.