Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals.

A spectrophotometric method is described for assay of pefloxacin mesylate (PFM) in bulk drug and in tablets. The method is based on back extraction of the bromophenol blue dye at pH 5.2 from the dye-drug ion pair followed by measurement of the dye absorbance at 590 nm.

Simple high-performance liquid chromatographic method for the determination of acyclovir in pharmaceuticals.

An assay method for the determination of acyclovir from pharmaceutical preparations has been developed for assessment of product quality utilising high-performance liquid chromatography. The chromatographic conditions comprised a reversed-phase C18 column (250 x 4.6 mm i.

Two simple methods for the estimation of albendazole and its dosage forms using chloramine-T.

Two simple, rapid and reliable methods for the determination of albendazole are described. Both methods involve the use of chloramine-T as the oxidimetric reagent. In the titrimetric method, a known excess of chloramine-T is added to an acidified solution of sample, and after a specified time, the residual oxidant is determined iodometrically.

Three useful bromimetric methods for the determination of salbutamol sulfate.

Three different methods developed for the determination of salbutamol sulfate (SBS), in pure drug form and in dosage forms, are discussed. The methods are based on the oxidation-bromination reaction of the drug by bromine generated in-situ by the interaction of bromate with bromide in acid medium. In titrimetry the drug is titrated directly with bromate in the presence of a large excess of bromide and in sulfuric acid medium using methyl red as indicator.

Use of an oxidation reaction for the quantitative determination of albendazole with Chloramine-T and acid dyes.

One titrimetric and two spectrophotometric procedures have been reported for the determination of albendazole and its tablets. Using titrimetry, the drug was titrated directly with Chloramine-T under acidic conditions using a Methyl Orange indicator. The spectrophotometric procedures involve treating the sample solution with a measured excess of Chloramine-T in an acid medium, followed by an estimation of unreacted Chloramine-T by reacting with a fixed amount of either Methyl Orange or Indigo Carmine dye solution and measuring the absorbance at 510 nm or 610 nm.