Nucleosome fibre topology guides transcription factor binding to enhancers.

Cellular identity requires the concerted action of multiple transcription factors (TFs) bound together to enhancers of cell-type-specific genes. Despite TFs recognizing specific DNA motifs within accessible chromatin, this information is insufficient to explain how TFs select enhancers. Here we compared four different TF combinations that induce different cell states, analysing TF genome occupancy, chromatin accessibility, nucleosome positioning and 3D genome organization at the nucleosome resolution.

Cu-incorporated NH-MIL-125(Ti): a versatile visible-light-driven platform for enhanced photocatalytic H generation and CO photoconversion.

Here, we present for the first time an efficient platform for simultaneous H generation and CO conversion into HCOOH, utilizing a Cu-incorporated NH-MIL-125(Ti) material with triethanolamine as the sacrificial agent. When subjected to light, Cu-NH-MIL-125(Ti) exhibits a remarkable enhancement in H generation, with a 30-fold increase under UV-Vis light and an 8-fold increase under visible irradiation compared to the pristine MOF. The study on the CO photoreduction ability of Cu-NH-MIL-125(Ti) indicated successful conversion into formic acid yielding 62.

Mitogenomic analysis of the position of the Azygiidae and constituent genera, with a new species of Azygia.

The Azygiidae Looss, 1899 is a family of digeneans with a Holarctic distribution in which members of some genera mature in marine elasmobranchs while others occur only in freshwater teleosts. Some have questioned whether the marine genus Otodistomum Stafford, 1904 indeed belongs to the same family as the freshwater azygiid genera, namely Azygia Looss, 1899, Proterometra Horsfall, 1933, and Leuceruthrus Marshall and Gilbert, 1905. We present phylogenetic analyses based on mitochondrial genomes, rDNA operons, and partial cytochrome c oxidase I (Cox1) sequences from North American and Asian species that support the monophyly of Azygiidae, and placement of Azygioidea in the suborder Hemiurata, in contrast to recently published mitochondrial genome phylogenies.

Illness Stigma and Shame in People With Chronic Illnesses vs. SARS-CoV-2 Survivors: Associations With Psychological Distress Through Psychological Flexibility and Self-Compassion.

Individuals with chronic illnesses and those infected with SARS-CoV-2 often face stigma, shame, and psychological distress related to their conditions. Higher psychological flexibility and self-compassion are often associated with less stigma and shame. Examining and comparing these experiences between people with chronic illness and people who have recovered from SARS-CoV-2 can provide valuable insights into the shared and unique challenges they encounter.