Publications by authors named "H C Hartmann"
3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel. Although hydrogels expose an ideal growth environment due to their extracellular matrix (ECM)-like properties, high water amount and tissue like microstructure, they lack mechanical strength and possess a diffusion limit of a couple of hundred micrometers. Integration of electrospun fibers could hereby benefit in multiple ways, for instance by controlling mechanical characteristics, cell orientation, direction of diffusion and anisotropic swelling behavior.
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- Biological 3D printing, or bioprinting, involves the automated creation of living cells and biomaterials and is considered an extension of additive manufacturing according to ASTM and ISO standards.
- While there's a lot of excitement about the potential clinical applications of bioprinting, many discussions overlook crucial steps necessary for translating this technology into real-world healthcare solutions.
- The article suggests modifying the technology readiness level (TRL) scale to assess the maturity of bioprinting research and offers recommendations to enhance future projects and ensure successful clinical integration.
Article Synopsis
- The concept of neurodiversity is complex and has many definitions, which can confuse those wanting to learn about it.
- A collaborative reading list created by neurodiverse researchers addresses the lack of curated information by covering nine key themes related to neurodiversity.
- The resource aims to enhance understanding of neurodiversity and guide researchers toward more inclusive and rigorous scientific practices.
In this work, the chemical equilibrium between enol and keto tautomers occurring in phenol, naphthols and selected 29 hydroxy substituted polycyclic aromatic hydrocarbons classified into 4 structural types was investigated. The reaction Gibbs energies were computed using the density functional theory combined with the solvent continuum model. We have demonstrated how the consecutive condensation of benzene rings together with two-dimensional molecular arrangement and the position of the hydroxyl group modifies this equilibrium.
View Article and Find Full Text PDFTenascin-C (TNC) is a secreted extracellular matrix protein that is highly expressed during embryonic development and re-expressed during wound healing, inflammation, and neoplasia. Studies in developmental models suggest that TNC may regulate the Wnt signaling pathway. Our lab has shown high levels of Wnt signaling and TNC expression in anaplastic thyroid cancer (ATC), a highly lethal cancer with an abysmal ~3-5 month median survival.
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