Publications by authors named "H C H Yim"
Colorectal malignancies associated with KRAS and TP53 mutations led us to investigate the effects of combination therapy targeting KRAS, MEK1, or PLK1 in colorectal cancer. MEK1 is downstream of RAS in the MAPK pathway, whereas PLK1 is a mitotic kinase of the cell cycle activated by MAPK and regulated by p53. Bioinformatics analysis revealed that patients with colorectal cancer had a high expression of MAP2K1 and PLK1.
View Article and Find Full Text PDFConcurrent Fabry disease and IgA nephropathy in a patient with Crohn's disease: A case report.
Nephrology (Carlton)
January 2025
Article Synopsis
- - A 27-year-old female with a decade-long history of Crohn's disease was diagnosed with both Fabry disease (FD) and IgA nephropathy (IgAN) after presenting with kidney issues, including microscopic hematuria and proteinuria.
- - Kidney biopsy results showed characteristics of IgAN, such as mesangial matrix widening, and electron microscopy revealed findings consistent with both IgAN and FD.
- - The diagnosis of FD was confirmed by low enzyme activity, leading to the start of enzyme replacement therapy; this case is notable as the first documented occurrence of FD, IgAN, and Crohn's disease coexisting in one patient.
Introduction And Objectives: The short-term mortality of severe alcoholic hepatitis (SAH) is high, but there are no effective treatments to improve short-term mortality other than corticosteroids. This study investigated the effects of adding rifaximin to standard treatment in patients with SAH.
Material And Methods: In this randomized controlled open-label trial, patients with SAH (Maddrey's discriminant function≥32) were randomized to the rifaximin or control group.
Combined nutcracker syndrome and glomerulonephritis in pediatric patients: a single-center retrospective case series.
Kidney Res Clin Pract
November 2024
Background: Nutcracker syndrome (NCS) has been reported to coexist with various glomerulonephritis (GN). This study investigated clinical features of NCS combined with GN in a pediatric case series and the possible relationship between these two conditions.
Methods: Clinical and pathologic findings of 15 children with NCS and biopsy-proven GN were analyzed.
Baveno VII criteria (B7C) and Baveno VI criteria (B6C) have been widely used to estimate the risk of hepatic decompensation. However, the impact of age on these criteria warrants further investigation. The international, multicenter cohort study included 1138 patients with compensated cirrhosis (median follow-up of 40.
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