Publications by authors named "H C Chui"
Background: The neuropathologies of Alzheimer's disease (AD) and Lewy body disease (LBD) commonly co-occur. Parkinsonism is the hallmark feature in LBD but it can be difficult to predict the presence of these co-pathologies early in the course of clinical disease. Timely diagnosis has crucial implications, especially with the advent of disease-modifying therapies.
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- A study was conducted to investigate the X-chromosome's role in Alzheimer's Disease (AD), which had been overlooked in previous genome-wide association studies.
- The research included 115,841 AD cases and 613,671 controls, considering different X-chromosome inactivation (XCI) states in females.
- While no strong genetic risk factors for AD were found on the X-chromosome, seven significant loci were identified, suggesting areas for future research.
Article Synopsis
- During the COVID-19 pandemic, healthcare systems were overwhelmed, and this study examined how spontaneous avoidance behaviors influenced the spread of infectious diseases through wastewater virus surveillance.
- The researchers developed the Su-SEIQR model to analyze these behaviors alongside COVID-19 data from Beijing and Hong Kong, confirming that collective avoidance helped lower infection peaks, though its overall impact on public health was limited.
- By incorporating healthcare capacity constraints, the model aims to advise public behaviors during outbreaks, offering valuable insights for future public health policies and the management of potential new viruses.
Structured light 3D shape measurement is extensively utilized in semiconductor inspection, smart manufacturing, and biomedical imaging due to its rapid measurement speed, high precision, and versatile applicability to different objects. However, the traditional implementations of this method often require that the object remains static while recording the phase-shifting structured light images, which limits the adaptability of dynamic measurement. Here, we propose a dynamic 3D shape measurement using structured light based on a motion-induced phase shift (MIPS).
View Article and Find Full Text PDFResting-state functional connectivity (FC) is suggested to be cross-sectionally associated with both vascular burden and Alzheimer's disease (AD) pathology. For instance, studies in pre-clinical AD subjects have shown increases of cerebral spinal fluid soluble platelet-derived growth factor receptor-β (CSF sPDGFRβ, a marker of BBB breakdown) but have not demonstrated if this vascular impairment affects neuronal dysfunction. It's possible that increased levels of sPDGFRβ in the CSF may correlate with impaired FC in metabolically demanding brain regions (i.
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