Periods of rest and sleep help us find hidden solutions to new problems and infer unobserved relationships between discrete events. However, the mechanisms that formulate these new, adaptive behavioural strategies remain unclear. One possibility is that memory reactivation during periods of rest and sleep has the capacity to generate new knowledge that extends beyond direct experience.
View Article and Find Full Text PDFPneumocoelom secondary to primary pulmonary disease was diagnosed via CT (three cases) or radiographs and coelioscopy (one case) in one Kemp's ridley () and three loggerhead () sea turtles. All cases were suspected to be caused by trauma to the lung, and all exhibited positive buoyancy disorders. Coelomocentesis alone was ineffective at resolving each pneumocoelom, suggesting a large and persistent tear in the pulmonary parenchyma.
View Article and Find Full Text PDFBackground: Buprenorphine is an effective and safe treatment for opioid use disorder, but the requirement for moderate opioid withdrawal symptoms to emerge prior to initiation is a significant treatment barrier.
Case Presentation: We report on two cases of hospitalized patients with severe, active opioid use disorder, in which we initiated treatment with transdermal buprenorphine over 48 h, followed by the administration of a single dose of sublingual buprenorphine/naloxone and then extended-release subcutaneous buprenorphine. The patients did not experience precipitated withdrawal and only had mild withdrawal symptoms.