Comparative evaluation of removal of oil-based calcium hydroxide intracanal medicaments with two calcium chelators: An cone-beam computed tomography volumetric analysis.

Background: Intracanal medicament (ICM) eliminates remaining bacteria and their toxins that were not removed by chemomechanical preparation during endodontic treatment.

Aim: The aim of this study was to compare and evaluate the removal of ozonated oil-based, silicone oil-based, and distilled water-based ICM with two calcium chelators, i.e.

Lipopolysaccharide differentially alters systemic and brain glucocorticoid levels in neonatal and adult mice.

Glucocorticoids (GCs) are secreted by the adrenal glands and increase in response to stressors (e.g., infection).

Insulin Efsitora versus Degludec in Type 2 Diabetes without Previous Insulin Treatment.

Background: Insulin efsitora alfa (efsitora) is a new basal insulin designed for once-weekly administration. Data on safety and efficacy have been limited to small, phase 1 or phase 2 trials.

Methods: We conducted a 52-week, phase 3, parallel-design, open-label, treat-to-target trial involving adults with type 2 diabetes who had not previously received insulin.