Publications by authors named "H Burgmann"
Article Synopsis
- The study evaluates the real-world effectiveness of two oral antivirals, nirmatrelvir-ritonavir and molnupiravir, against the Omicron variant of SARS-CoV-2 in non-hospitalized adults.
- Data were obtained from a retrospective cohort study involving over 113,000 confirmed cases of Covid-19, comparing treated patients with untreated controls to assess risks of hospitalization and death within 28 days.
- Results showed that nirmatrelvir-ritonavir significantly reduced hospitalization and death rates, especially in individuals aged 60 and older; however, molnupiravir did not show a significant difference in these outcomes compared to untreated controls.
Impaired immune response to COVID-19 (coronavirus disease 2019) vaccination has been reported in patients with inborn errors of immunity (IEI). Repetitive vaccinations are recommended for this vulnerable group. Due to the high diversity within IEI patients, additional safety and immunogenicity data are needed to better understand these aspects especially in less common immunodeficiency syndromes.
View Article and Find Full Text PDFThe global nitrogen (N) cycle has been strongly altered by anthropogenic activities, including increased input of bioavailable N into aquatic ecosystems. Freshwater sediments are hotspots with regards to the turnover and elimination of fixed N, yet the environmental controls on the microbial pathways involved in benthic N removal are not fully understood. Here, we analyze the abundance and expression of microbial genes involved in N transformations using metagenomics and -transcriptomics across sediments of 12 Swiss lakes that differ in sedimentation rates and trophic regimes.
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- * Researchers analyzed 4121 enterococcal bloodstream infection episodes, identifying 80 instances of IE, and found that various treatment combinations were used, including monotherapies and combinations involving aminopenicillins.
- * Overall, the study concluded that monotherapy regimens, particularly with aminopenicillins, may be effective for treating IE, suggesting the need for further prospective research to validate these findings.
Background: Environmental reservoirs of antibiotic resistance pose a threat to human and animal health. Aquatic biofilms impacted by wastewater effluent (WW) are known environmental reservoirs for antibiotic resistance; however, the relative importance of biotic factors and abiotic factors from WW on the abundance of antibiotic resistance genes (ARGs) within aquatic biofilms remains unclear. Additionally, experimental evidence is limited within complex aquatic microbial communities as to whether genes bearing low sequence similarity to validated reference ARGs are functional as ARGs.
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