Publications by authors named "H Burdett"
DNA methyltransferase 3A (DNMT3A) plays a critical role in establishing and maintaining DNA methylation patterns in vertebrates. Here we structurally and biochemically explore the interaction of DNMT3A1 with diverse modified nucleosomes indicative of different chromatin environments. A cryo-EM structure of the full-length DNMT3A1-DNMT3L complex with a H2AK119ub nucleosome reveals that the DNMT3A1 ubiquitin-dependent recruitment (UDR) motif interacts specifically with H2AK119ub and makes extensive contacts with the core nucleosome histone surface.
View Article and Find Full Text PDFSocial support is a key determinant of mental health across multiple populations and contexts. Little is known about social support among UK (ex-)military personnel, especially those with combat injuries following deployment to Afghanistan. This study aimed to investigate the level of perceived social support and its associations with mental health among injured and uninjured UK (ex-)military personnel.
View Article and Find Full Text PDFPositive species interactions structure rhodolith bed communities at a global scale.
Biol Rev Camb Philos Soc
September 2024
Article Synopsis
- * They act as foundation species, creating "facilitation cascades" that help mitigate physical stress, reduce predator impacts, and improve resource availability for other species, which leads to complex and supportive community structures.
- * Key research gaps include understanding how rhodoliths function as facilitators, the stability of these interactions over time, how species dynamics change in different environments, and their potential as climate refuges, which is essential for shaping effective marine conservation policies.
Article Synopsis
- - Red coralline algae play a vital role in coastal reef ecosystems and carbon cycling, but their physiology is not well understood, especially the relationship between carbon production and sequestration.
- - Using dual radioisotope tracing, the study shows that these algae couple photosynthesis and calcification, with significant portions of carbon being stored in their skeletons and organic matter.
- - The research indicates that calcifying algae might actually contribute less to carbon dioxide release than previously thought, highlighting the need for a reevaluation of their impact on oceanic carbon storage.
Purpose: Combat deployment increases exposure to potentially traumatic events. Perceived social support (PSS) may promote health and recovery from combat trauma. This systematic review and meta-analysis aimed to synthesize studies investigating the level of PSS and associated factors among (ex-)military personnel who served in the Iraq/Afghanistan conflicts.
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