Publications by authors named "H Bugaut"
Article Synopsis
- Intestinal inflammation alters the composition and metabolism of gut microbiota, but the host's response to these changes is not fully understood.* -
- Mucosal-associated invariant T (MAIT) cells can detect metabolites from riboflavin-producing bacteria that increase during inflammation, promoting tissue repair in the intestines.* -
- Mice without MAIT cells showed higher susceptibility to colitis and related colorectal cancer, highlighting the significance of MAIT cells in responding to gut inflammation through bacterial metabolic pathways.*
Mucosal-associated invariant T (MAIT) cells harbor evolutionarily conserved TCRs, suggesting important functions. As human and mouse MAIT functional programs appear distinct, the evolutionarily conserved MAIT functional features remain unidentified. Using species-specific tetramers coupled to single-cell RNA sequencing, we characterized MAIT cell development in six species spanning 110 million years of evolution.
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- This study examines the relationship between neutrophilic dermatosis (ND), hidradenitis suppurativa (HS), and Behçet's disease (BD), noting shared traits that suggest a common underlying cause.
- The research identified 20 patients (out of 1462 experiencing BD) with ND or HS, finding a relatively high occurrence of pyoderma gangrenosum (PG) among them, which highlights the unique clinical features and responses to treatment in these patients.
- Treatment options including colchicine, glucocorticoids, and various biologic therapies like anti-TNFα have shown promising results for managing refractory cases of ND and HS in the context of BD.