Publications by authors named "H Bracq-Dieye"
Microbial pathogenesis is mediated by the expression of virulence genes. However, as microbes with identical virulence gene content can differ in their pathogenic potential, other virulence determinants must be involved. Here, by combining comparative genomics and transcriptomics of a large collection of isolates of the model pathogen Listeria monocytogenes, time-lapse microscopy, in vitro evolution and in vivo experiments, we show that the individual stress responsiveness of L.
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- Listeriosis, an infection caused by Listeria monocytogenes, can lead to a rare form called spontaneous bacterial peritonitis, which was the focus of a nationwide study using data from France between 1993 and 2022.
- The study included 208 patients diagnosed with L monocytogenes-associated peritonitis and found that most were older males with significant immunosuppressive health issues, particularly cirrhosis and alcoholism.
- The symptoms were often mild or vague, with only half of the patients showing common signs like fever or abdominal pain, highlighting the challenges in diagnosing this condition.
Background: Large-scale studies are needed to clarify antimicrobial resistance in the foodborne pathogen () and the effectiveness of listeriosis treatment options. Here we examined the antimicrobial resistance patterns in over time and assessed genotype-phenotype concordances.
Methods: We analyzed 5339 isolates (2908 clinical and 2431 food isolates) collected in France and overseas territories, between 2012 and 2019.
Genomic data on the foodborne pathogen Listeria monocytogenes from Central America are scarce. We analyzed 92 isolates collected during 2009-2019 from different regions in Costa Rica, compared those to publicly available genomes, and identified unrecognized outbreaks. Our findings suggest mandatory reporting of listeriosis in Costa Rica would improve pathogen surveillance.
View Article and Find Full Text PDFWe report a case of fulminant fatal neonatal listeriosis due to horizontal transmission of Listeria monocytogenes (Lm) in a neonatal double room. Genomic analyses reveal a close genetic relationship between clinical isolates, supporting cross-contamination. Oral inoculation experiments in adult and neonatal mice show that neonates are susceptible to a low Lm inoculum and that this susceptibility results from the immaturity of the neonatal gut microbiota.
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