Design and synthesis of novel thioether analogs as promising antiviral agents: In vitro activity against enteroviruses of interest.

The Enterovirus genus contains two major subgroups: rhinovirus (RV) species A-C and enterovirus (EV) ones A-D. While RV only infects the respiratory system, the EV can cause a wide variety of diseases, ranging from non-specific febrile illness to severe neurologic complications. To date, no curative treatments are commercially available.

Cytotoxic Response of CD4 T Cells Orchestrated by SLAMF4 in Rheumatoid Arthritis.

Objective: This study aimed to assess whether signaling lymphocytic activation molecule family receptors (SLAMFs) are involved in the shaping of the pathologic response of CD4 T cells in rheumatoid arthritis (RA).

Methods: Peripheral blood (PB) and synovial fluid (SF) mononuclear cells from patients with RA were freshly isolated. In RA, we used a multimodal approach to determine the involvement of numerous subpopulations of CD4 T cells expressing SLAMFs.

Chronic total occlusion- Percutaneous coronary intervention (CTO-PCI) experience in a single, multi-operator Tunisian center : A Five-Year Report.

Introduction: In recent years, advancements in chronic total occlusion (CTO) percutaneous coronary intervention (PCI) have been notable, improving procedural techniques, imaging, and management of complications.

Aim: We sought to assess the performance and the practice of a high-volume Tunisian PCI center in treating patients with a CTO.

Methods: We retrospectively evaluated data from consecutive CTO patients who underwent percutaneous revascularization from October 2019 to January 2024 at the cardiology department of Habib Thameur Teaching Hospital, Tunisia.

Role of pulmonary ultrasonography in diagnosis of acute heart failure.

Background: One of the most prevalent causes of emergency room visits is acute dyspnea. Several etiologies, including cardiac, pulmonary, metabolic, psychogenic etc… may be involved. Acute heart failure (AHF) is among the most common causes.